PFE announced that the European Commission (EC) has approved an expanded indication for its meningococcal vaccine, Nimenrix. We note that Pfizer has outperformed the Zacks classified Large Cap Pharmaceuticals industry year to date. In fact, the company has gained 1.8% so far this year, compared to a drop of 6.0% for the industry. Coming back to the news, Nimenrix was approved for active immunization against invasive meningococcal disease (IMD) caused by Neisseria meningitidis serogroups A, C, W-135, and Y (MenACWY) in infants as young as six weeks of age. The vaccine was earlier approved for the same indication in individuals aged six weeks and above. We note that Pfizers meningococcal vaccines portfolio includes vaccines that help fight against the five most common disease-causing serogroups A, C, W-135, Y, and B (approvals varying by country). Note that Pfizer has been focused on deploying increased resources for the development of treatments in the fields of oncology, cardiology, metabolic disorders, neuroscience, pain, rare diseases, immunology, inflammation and vaccines as well as immuno-oncology. Concurrently, Pfizer announced encouraging results from a sub-analysis on the phase III trial, PALOMA- 2, on Ibrance, in combination with Femara, as first-line therapy for postmenopausal women with estrogen receptor-positive, human epidermal growth factor receptor 2-negative (ER+, HER2-) metastatic breast cancer. The study is being conducted among Asian patients. The results showed that the combination of Ibrance and Femara significantly extended progression-free survival (PFS) by more than 11 months, compared with Femara plus placebo, along with demonstrating that the median PFS exceeded two years in these patients.
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The CADScorSystem fills a major gap in the Coronary Artery Disease diagnostic pathway by combining acoustic detection of turbulent arterial flow and myocardial movement with advanced algorithms in a handheld device to provide a patient specific CAD-Score in less than 10 minutes. CE-Marked, the CADScorSystem is due for commercial launch in 2017, initially in selected European markets. Sren Rysholt Christiansen commented: “Medtech Showcase provides an immediate opportunity for us to capitalize on the major interest generated by our recent successful IPO. We look forward to meeting with both potential US and international collaborators as we accelerate our commercial efforts to bring CADScorSystem to market and thus help impact and improve Coronary Artery Disease diagnosis and management.” Contacts: Notes to editors: Acarix , CADScorSystem and cardiac sound measurement Acarix A/S was established in 2009, and since 2010 investors SEED Capital (DK) and Sunstone Life Science Ventures (DK) have supported it towards market introduction. Acarix has attracted a highly-experienced management team who have held senior positions in international medical device companies – CEO Sren Rysholt Christiansen with ELOS Medtech, GN ReSound and Cook Medical. Acarix`s CADScorSystem is based on engineering excellence in sound recording and signal processing. It has long been known that both cardiac contraction movement and turbulent flow can generate sound. Contraction related sounds are in lower frequency, whereas turbulent sounds in the streaming blood caused by partial obstruction (stenosis) in the coronary arteries are of higher frequencies. The detection of these murmurs is delicate, since the energy of the murmurs is very weak. http://mesadiewright.accessnetwork.us/2016/11/15/the-emerging-opportunities-in-deciding-on-necessary-details-for-tips-for-job-interviewDetecting and recording the coronary murmurs requires not only an advanced sensor but also means for proper attachment to the skin above the heart to optimize the recorded signal and to avoid external noise. The Acarix CADScorSystem has been designed to be an all-in-one system in the sense that the heart signal will be recorded, processed and displayed as a patient specific score, the CAD-score, on the device screen.interview skill
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