Piezo2-deficient newborn mice showed unexpanded lungs and significantly shallow breathing. “The lungs communicate with the brain via sensory neurons. The Piezo2 channel in sensory neurons generates a message about lung volume changes, and Piezo2-containing sensory neurons deliver this message to the brain,” said TSRI Research Associate Keiko Nonomura, co-first author of the study with TSRI Research Associate Seung-Hyun Woo. “Piezo2-deficient mice cannot generate an accurate message about their lung volume changes. As a result, these mice cannot receive proper output from the brain.” Strikingly, according to recently published papers, Piezo2-deficient human infants also show shallow breathing and require medical attention. “Piezo2-deficient newborn mice develop normally until birth. newsThe problem only arise once the mice are born and try to breathe on their own” added Nonomura. Consequences in Adult Mice The researchers were surprised to see an unexpected consequence of deleting Piezo2 in sensory neurons of adult mice. When the Piezo2 channel was deleted either in all sensory neurons or only from vagal sensory neurons, adult mice could still breathe, but they inhaled significantly more air than Piezo2-intact mice. http://www.youtube.com/watch?v=Pf7JuJcVzQUUnder normal conditions, animals stop breathing when they are forced to breathe in more air, but Piezo2-deficient adult mice lacked the Hering-Breuer reflex and continued breathing when they were forced to breathe in more air.interview skills resources
For the original version including any supplementary images or video, visit https://www.eurekalert.org/pub_releases/2016-12/sri-tsp122216.php
(AP) Quinndary Weatherspoon had a career-high 27 points to lead Mississippi State to an 85-76 victory over Morehead State Thursday at Humphrey Coliseum. Weatherspoon had 15 points in the second half as the Bulldogs (8-3) overcame a 10-point halftime deficit. Weatherspoon also set a career-high with 10 made field goals on 17 attempts from the floor. I.J. http://camdencrawfordfocus.redcarolinaparaguay.org/2017/01/29/some-questions-for-essential-aspects-in-careerReady had 19 points for Mississippi State and Aric Holman added 12. Xavier Moon led Morehead State with 22 points while Lamontray Harris had 20 points and Jordan Walker 10 for the Eagles. The first half featured six ties and three lead changes in the first six minutes. But Morehead State used a 13-4 run midway through the first half to grab control. The Eagles (3-9) shot 57 percent in the first half, including a 5-of-10 showing on 3 pointers, and held a 41-31 halftime advantage. Meanwhile, Mississippi State shot just 44 percent in the first half and made just 1 of 8 beyond the arc.
For the original version including any supplementary images or video, visit http://www.wcbi.com/career-high-weatherspoon-helps-bulldogs-rally-past-morehead-state/
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